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series of experiments conducted on mice highlights the central role of mast cells in the mechanism of inflammatory arthritis.These immune cells respond to various signals inflammatory and would have an active role in the pathophysiology of inflammatory arthritis.
This discovery is being published in the edition of the journal Science dated September six. David Lee and colleagues of the Medical School of Harvard recall that the precise mechanisms of inflammatory arthritis (RA) are still poorly understood.
Previous studies have highlighted the role of many factors soluble and cellular differentiation (auto-antibodies, complement components, Fc receptors), but the sequence of steps that lead to disease remains subject to bail.
According to Lee, et al. Mast, which are located in the connective tissue and are associated with a large number of allergies, could be involved in the onset of arthritis.
The researchers studied mice without mast and they showed they were resistant to the development of a joint inflammation. Unlike normal mice, rodents lacking mast have not developed arthritis after injecting a serum containing inflammatory signals.
By cons, sensitivity to this serum was restored when the mice received a transplant of mast cells, the researchers stressed. "Thus, the mast could function as a link between the cellular self-antibodies, soluble mediators and other populations of effectors in the inflammatory polyarthritis," they write.
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